The Effect of H-ras and C-myc Oncogene Transfection on the Response of Lung Epithelial Cells to Growth Factors and Cytotoxic Drugs
Clinical applications consequent upon elucidation of the role of oncogenes in contributing to the malignant cellular phenotype have mainly focussed on refinement of existing prognostic models for patient survival. Current research on breast cancer has shown a relationship between amplification of the c-erbB-2 or Her-2/neu oncogenes and disease progression and patient survival (Slamon et al, 1987). Similarly, amplification of the N-myc oncogene was found consistently in patients with advanced state neuroblastoma which was relatively resistant to chemotherapy (Schwab et al, 1984). The association between oncogene expression and prognosis could be due to two related variables: oncogene activation could be associated with a particularly aggressive malignant phenotype, e.g. they could confer metastability; or the oncogenes could confer cellular drug resistance to conventional chemotherapy resulting in a tumour refractory to standard therapy. A number of in vitro studies have indicated that oncogene transfection of immortalised cells can result in relative resistance to a number of antineoplastic drugs, including cisplatin (Sklar 1988).
KeywordsBromide Glycine Dimethyl Trypsin Doxorubicin
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