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Oncogene Expression and Cervical Cancer

  • R. P. Symonds
  • T. Habeshaw
  • J. Paul
  • D. J. Kerr
  • A. Darling
  • R. A. Burnett
  • F. Sotsiou
  • S. Linardopoulos
  • D. A. Spandidos
Part of the NATO ASI Series book series (NSSA, volume 220)

Abstract

Evidence strongly suggests that oncogene expression is an important factor in the initiation and development of a range of malignant tumours including carcinoma of cervix (Slamon, 1987). Some patients with histologically similar tumours at the same clinical stage treated the same way do better or worse than others. Prognosis, radiosensitivity and chemotherapy resistance may be affected by oncogene expression. Riou and colleagues (1987) have shown that surgically treated patients with early stage (I and IIa) disease whose tumours show c-myc overexpression have an eight-fold increase in the incidence of relapse compared to other patients.

Keywords

Cervical Cancer Oncogene Expression Oncogene Amplification Oncoprotein Expression Term Disease Free Survival 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • R. P. Symonds
    • 1
  • T. Habeshaw
    • 1
  • J. Paul
    • 1
  • D. J. Kerr
    • 1
  • A. Darling
    • 2
  • R. A. Burnett
    • 3
  • F. Sotsiou
    • 4
  • S. Linardopoulos
    • 5
  • D. A. Spandidos
    • 5
  1. 1.Beatson Oncology CentreWestern InfirmaryGlasgowUK
  2. 2.Beatson Institute for Cancer ResearchGlasgowUK
  3. 3.Department of PathologyWestern InfirmaryGlasgowUK
  4. 4.Department of PathologyEvangelismos HospitalAthensGreece
  5. 5.National Hellenic FoundationInstitute of Biological Research and BiotechnologyAthensGreece

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