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The Drosophila ras2/cs1 Bidirectional Promoter Shares Consensus Sequences with the Human c-Ha-ras1 Promoter

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The Superfamily of ras-Related Genes

Part of the book series: NATO ASI Series ((NSSA,volume 220))

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Abstract

A very high proportion — up to 30% of a variety of human tumours including carcinomas, sarcomas and neuroblastomas contain activated ras oncogenes1. Several mechanisms which activate the transforming potential of normal ras cellular genes have been described2. In some cases alteration of the regulatory sequences of the gene may also induce its transforming activity3. Evidence exist for the role of enhanced expression of the normal ras onco-protein in ras activation in human tumours. Increase amounts of the normal ras protein were observed in breast carcinomas, lung, colon, bladder and gastric cancers4 and in bone marrow cells from patients with Myelo dysplastic syndrome5.

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Author information

Authors and Affiliations

  1. Department of Zoology, University of the Witwatersrand, P O Wits 2050, Johannesburg, South Africa

    O. Segev & K. Lightfoot

Authors
  1. O. Segev
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  2. K. Lightfoot
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Editor information

Editors and Affiliations

  1. National Hellenic Research Foundation, Athens, Greece

    Demetrios A. Spandidos

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© 1991 Plenum Press, New York

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Segev, O., Lightfoot, K. (1991). The Drosophila ras2/cs1 Bidirectional Promoter Shares Consensus Sequences with the Human c-Ha-ras1 Promoter. In: Spandidos, D.A. (eds) The Superfamily of ras-Related Genes. NATO ASI Series, vol 220. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6018-6_29

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  • DOI: https://doi.org/10.1007/978-1-4684-6018-6_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6020-9

  • Online ISBN: 978-1-4684-6018-6

  • eBook Packages: Springer Book Archive

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