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The Drosophila ras2/cs1 Bidirectional Promoter Shares Consensus Sequences with the Human c-Ha-ras1 Promoter

  • O. Segev
  • K. Lightfoot
Part of the NATO ASI Series book series (NSSA, volume 220)

Abstract

A very high proportion — up to 30% of a variety of human tumours including carcinomas, sarcomas and neuroblastomas contain activated ras oncogenes1. Several mechanisms which activate the transforming potential of normal ras cellular genes have been described2. In some cases alteration of the regulatory sequences of the gene may also induce its transforming activity3. Evidence exist for the role of enhanced expression of the normal ras onco-protein in ras activation in human tumours. Increase amounts of the normal ras protein were observed in breast carcinomas, lung, colon, bladder and gastric cancers4 and in bone marrow cells from patients with Myelo dysplastic syndrome5.

Keywords

Ras2 Gene Bidirectional Promoter Chloramphenicol Acetyl Transferase Large Protein Complex Myelo Dysplastic Syndrome5 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • O. Segev
    • 1
  • K. Lightfoot
    • 1
  1. 1.Department of ZoologyUniversity of the WitwatersrandJohannesburgSouth Africa

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