Ha-ras-1 Transfected Cells: Induction to Differentiation by Natural and Synthetic Retinoids

  • Claudio Nastruzzi
  • Demetrios Spandidos
  • Giordana Feriotto
  • Stefano Manfredini
  • Daniele Simoni
  • Roberto Gambari
Part of the NATO ASI Series book series (NSSA, volume 220)


The in vitro activity of natural retinoids (retinoic acid and retinol) and new classes of synthetic analogues of retinoids on differentiation of chinese hamster fibroblasts transfected with either the normal (FH06N1–1) or the activated (FH06T1–1) Ha-ras-1 oncogene is reported. The most active synthetic retinoids were found to induce adipogenic conversion of both FH06N1–1 and FH06T1–1 cell lines in a range comprised between 10 to 50 μM, concentrations that are 2 to 10 times lower than those required in the case of natural retinoids.


Retinoic Acid Synthetic Retinoid Promyelocytic Leukemia Cell Line Human Promyelocytic Leukemia Cell Line Chinese Hamster Fibroblast 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Claudio Nastruzzi
    • 1
  • Demetrios Spandidos
    • 2
  • Giordana Feriotto
    • 3
  • Stefano Manfredini
    • 1
  • Daniele Simoni
    • 1
  • Roberto Gambari
    • 3
  1. 1.Dipartimento di Scienze FarmaceuticheUniversità di FerraraItaly
  2. 2.National Hellenic Research FoundationAthensGreece
  3. 3.Istituto di Chimica BiologicaUniversità di FerraraItaly

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