Suppression of the Phenotype of T24 H-ras1 Transformed Cells
Many tumors contain activated ras genes (Bos, 1989; Field and Spandidos, 1990). These genes are thought to be involved in the development of these cancers. It would be of great therapeutic value to find ways to prevent these cancer cells growing. Therefore it is of interest to explore methods by which the growth of ras transformed cells is controlled i.e. suppression of cancer phenotype. These studies are more easily undertaken in vitro i.e. in tissue culture systems than in vivo and in this paper we will concentrate on the in vitro studies. A recent review has classified the suppression of ras transformants into three groups (Kuzumaki, 1991). Viz. 1. Those that operate through genetic material (genetical). 2. Those that operate through biological response modifiers (biological) and 3. Drugs (pharmaceutical) (see Table 1).
KeywordsTumorigenic Phenotype Growth Inhibitory Substance Chinese Hamster Lung Cell Skeletal Myoblast Differentiation Metallothionin Promoter
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