Effects of Hypertension on Arterial Gene Expression and Atherosclerosis

  • Aram V. Chobanian
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 308)


Hypertension may induce major changes in the arterial intima and media which may lead to arterial injury and atherosclerosis. Although the mechanisms involved in these alterations have not been clearly defined, recent studies in our own and other laboratories have demonstrated changes in gene expression of certain growth factors and functionally important proteins in response to blood pressure elevation or to vasoactive agents. This paper reviews these observations and also summarizes some recent data on the effects of antihypertensive drugs on atherogenesis.


Vascular Smooth Muscle Cell Fatty Acid Binding Protein Aortic Tissue Liver Fatty Acid Binding Protein Aortic Atherosclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Aram V. Chobanian
    • 1
  1. 1.Boston University School of MedicineBostonUSA

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