Reduced Aortic and Arteriolar Growth by Captopril in Normotensive and Renal Hypertensive Rats
The influence of angiotensin II (AII) on vascular structure has been widely studied. Much evidence from in vitro experiments indicate that AII stimulates DNA and protein synthesis in cardiovascular tissue and induces hypertrophy in rat and human vascular smooth muscle cells. In vivo experiments using converting enzyme inhibition in hypertensive rats have been confounded with pressure decreases which can also reduce vascular wall structure. This experiment was designed to evaluate the effect of the renin-angiotensin system on microvascular function and structure in normotension and renal hypertension, and to determine whether captopril alters cross-sectional area of the aortic and arteriolar wall. These are the first whole animal data to show effects on aortic and microvascular wall growth when the production of AII is blocked and the animals are still hypertensive.
KeywordsRenal Artery Stenosis Renal Hypertension Human Vascular Smooth Muscle Cell Small Arteriole Arteriolar Wall
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