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Effects of Bufalin on Renal Venous Outflow, Urine Flow and Natriuresis in the Anesthetized Dog

  • D. Eliades
  • M. B. Pamnani
  • B. T. Swindall
  • F. J. Haddy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 308)

Abstract

Recent studies suggest that the endogenous digitalis-like substance (DLS) implicated in the pathogenesis of low renin hypertension in animals and humans may be a steroidal dienolide derivative. One of these derivatives, bufalin (aglycone), inhibits Na+,K+-ATPase (1) and has recently been shown in our laboratory to have some of the physiological characteristics expected of a DLS (2). For example, infusion of bufalin into the brachial artery of the anesthetized dog increases vascular resistance and blocks K+ vasodilation while it potentiates norepinephrine vasoconstriction (Fig. 1). When bufalin is administered intravenously in the dog, increases in heart rate, dP/dt, and arterial blood pressure ensue (Fig. 2). In some animals (3/7) post-infusion natriuresis and diuresis occurs. Intravenous infusion in the rat likewise produces increases in blood pressure, heart rate, and dP/dt, and marked diuresis, natriuresis and kaliuresis (3) during and post-infusion. The present study in the anesthetized dog has been designed to examine the mechanism for the post-infusion natriuresis and diuresis seen with bufalin.

Keywords

Urine Flow Sodium Excretion Toad Skin ATPase Inhibitor Renal Venous Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • D. Eliades
    • 1
  • M. B. Pamnani
    • 1
  • B. T. Swindall
    • 1
  • F. J. Haddy
    • 1
  1. 1.Department of PhysiologyUniformed Services UniversityBethesdaUSA

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