Ca/CaM-Stimulated and cGMP-Specific Phosphodiesterases in Vascular and Non-Vascular Tissues

  • H. S. Ahn
  • M. Foster
  • M. Cable
  • B. J. R. Pitts
  • E. J. Sybertz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 308)


A large body of evidence indicates that guanosine 3’,5’-cyclic monophosphate (cGMP) plays an essential role in vasorelaxant actions of various agents such as atrial natriuretic factor (ANF), nitrogen oxide containing compounds (e.g., nitroprusside) and endothelium dependent vasodilators (e.g., acetylcholine) (1). These agents elevate cGMP by stimulating either soluble or particulate guanylate cyclase (1).


Bovine Brain Atrial Natriuretic Factor Cyclic Nucleotide Phosphodiesterase cAMP Hydrolysis cGMP Hydrolysis 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • H. S. Ahn
    • 1
  • M. Foster
    • 1
  • M. Cable
    • 1
  • B. J. R. Pitts
    • 1
  • E. J. Sybertz
    • 1
  1. 1.Department of PharmacologySchering-Plough Research DivisionBloomfieldUSA

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