Regulation of Human Cardiac Myosin Heavy Chain Gene Expression by Thyroid Hormone

  • E. Morkin
  • J. G. Edwards
  • R. W. Tsika
  • J. J. Bahl
  • I. L. Flink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 308)


Rat cardiac myosin heavy chain (MHC) genes are regulated in ventricular myocardium by 3,5,3′-triiodo-L-thyronine (T3), which stimulates expression of the α-MHC gene and decreases β-MHC mRNA production (1,2). The protein products of the cardiac MHC genes combine to produce three heavy chain isoforms, V1(α,α), V2(α,β), and V3(β,β), in order of decreasing electrophoretic mobility and Ca2+-ATPase activity (3). The relative proportions of these isoforms may be functionally important because the speed of contraction in both cardiac and skeletal muscles has been shown to be related to myosin ATPase (4). Recently, some forms of familial hypertrophic cardiomyopathy have been reported to be linked directly to either a partial duplication of the cardiac MHC genes or to a missense mutation of the β-MHC gene (5,6)


Thyroid Hormone Myosin Heavy Chain Thyroid Hormone Receptor Growth Hormone Gene Heavy Chain Gene 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • E. Morkin
    • 1
  • J. G. Edwards
    • 1
  • R. W. Tsika
    • 1
  • J. J. Bahl
    • 1
  • I. L. Flink
    • 1
  1. 1.Departments of Internal Medicine, Physiology and PharmacologyUniversity Heart Center Arizona Health Sciences CenterTucsonUSA

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