Ionic Channels of Vascular Smooth Muscle in Hypertension
Altered handling of ions by the vascular muscle membrane is viewed as a potential mechanism contributing to the development and maintenance of high blood pressure. This hypothesis is based on the premise that disturbances in membrane function may enhance vascular reactivity and increase total peripheral resistance. However, while there is a large body of evidence linking an increase in total peripheral resistance with the established stage of hypertension in many animal models of hypertension and in human essential hypertension (for review, 1), pinpointing cellular membrane abnormalities related to the genesis or maintenance of hypertension has been difficult.
KeywordsMembrane Potential Calcium Current Total Peripheral Resistance Calcium Channel Activation Caudal Artery
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