Ionic Channels of Vascular Smooth Muscle in Hypertension

  • Nancy J. Rusch
  • William J. Stekiel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 308)


Altered handling of ions by the vascular muscle membrane is viewed as a potential mechanism contributing to the development and maintenance of high blood pressure. This hypothesis is based on the premise that disturbances in membrane function may enhance vascular reactivity and increase total peripheral resistance. However, while there is a large body of evidence linking an increase in total peripheral resistance with the established stage of hypertension in many animal models of hypertension and in human essential hypertension (for review, 1), pinpointing cellular membrane abnormalities related to the genesis or maintenance of hypertension has been difficult.


Membrane Potential Calcium Current Total Peripheral Resistance Calcium Channel Activation Caudal Artery 


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  1. 1.
    Stekiel WJ. Electrophysiological mechanisms of force development by vascular smooth muscle membrane in hypertension. In: Blood Vessel Changes in Hypertension: Structure and Function, Vol. II, R.M.K.W. Lee (ed), Boca Raton: CRC Press, Boca Raton, 1989, p 127.Google Scholar
  2. 2.
    Hamill OP, Marty A, Naher S, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch39: 85, 1981.CrossRefGoogle Scholar
  3. 3.
    Frohlich ED. Is the spontaneously hypertensive rat a model for human hypertension? J Hypertension4: S15. 1986.Google Scholar
  4. 4.
    Mulvany MJ, Korsgaard N, Nyborg M. Evidence that the increased calcium sensitivity of resistance vessels in spontaneously hypertensive rats is an intrinsic defect of their vascular smooth muscles. Clin Exp Hypertens3: 749, 1981.PubMedCrossRefGoogle Scholar
  5. 5.
    Rusch NJ, Hermsmeyer K. Calcium currents are altered in the vascular muscle cell membrane of spontaneously hypertensive rats. Circ Res63: 997, 1988.PubMedGoogle Scholar
  6. 6.
    Sturek M, Hermsmeyer K. Calcium and sodium channels in spontaneously contracting vascular muscle cells. Science233: 475, 1986.PubMedCrossRefGoogle Scholar
  7. 7.
    Ljung B, Stage D, Carlsson C. Postnatal ontogenetic development of neurogenic and myogenic control in the rat portal vein. Acta Physiol Scand94: 112, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Lais LT, Rios LL, Boutelle S, DiBona GF, Brody MJ. Arterial pressure development in neonatal and young spontaneously hypertensive rats. Blood Vessels14: 277, 1977.PubMedGoogle Scholar
  9. 9.
    Safar ME, London GM. Venous system in essential hypertension, Clin Sci69: 497, 1985.PubMedGoogle Scholar
  10. 10.
    Kwan CY. Dysfunction of calcium handling by smooth muscle in hypertension. Can J Physiol Pharmacol63: 366, 1985.PubMedCrossRefGoogle Scholar
  11. 11.
    Bean BP, Sturek M, Puga A, Hermsmeyer K. Calcium channels in muscle cells isolated from rat mesenteric arteries: Modulation by dihydropyridine drugs. Circ Res59: 229, 1986.PubMedGoogle Scholar
  12. 12.
    Rorsman P, Trube G. Calcium and delayed potassium currents in mouse pancreatic B-cells under voltage-clamp conditions. J Physiol374: 531, 1986.PubMedGoogle Scholar
  13. 13.
    Toro L, Stefani E. Ca2+ and K+ current in cultured vascular smooth muscle cells from rat aorta. Pflügers Arch 408: 417, 1987.PubMedCrossRefGoogle Scholar
  14. 14.
    Wang R, Karpinski E, Pang PKT. Two types of calcium channels in isolated smooth muscle cells from rat tail artery. Am J Physiol256: H1361, 1989.PubMedGoogle Scholar
  15. 15.
    Hermsmeyer K. Electrogenesis of increased norepinephrine sensitivity of arterial vascular muscle in hypertension. Circ Res38: 362, 1976.PubMedGoogle Scholar
  16. 16.
    Droogmans G, Raeymaekers L, Casteels R. Electro-and pharmacomechanical coupling in the smooth muscle cells of the rabbit ear artery. J Gen Physiol70: 129, 1977.PubMedCrossRefGoogle Scholar
  17. 17.
    Haeusler G. Relationship between noradrenaline-induced depolarization and contraction in vascular smooth muscle. Blood Vessels15: 46, 1978.PubMedGoogle Scholar
  18. 18.
    Harder DR, Belarinelli L, Sperelakis N, Rubio R, Berne RM. Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. Circ Res44: 176, 1979.PubMedGoogle Scholar
  19. 19.
    Bryant HJ, Harder DR, Pamnani MB, Haddy FJ. In vivo membrane potentials of smooth muscle cells in the caudal artery of the rat. Am J Physiol249: C78, 1985.Google Scholar
  20. 20.
    Stekiel WJ, Contney SJ, Lombard JH. Small vessel membrane potential, sympathetic input, and electrogenic pump rate in SHR. Am J Physiol19: C547, 1986.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Nancy J. Rusch
    • 1
  • William J. Stekiel
    • 1
  1. 1.Department of PhysiologyMedical College of WisconsinMilwaukeeUSA

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