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Time Dependent Heterodimer Formation Leads to Inhibition of HIV Protease Activity

  • Lilia M. Babé
  • Charles S. Craik
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)

Abstract

The protease encoded by the human immunodefiency virus (HIV) is a homodimer as determined by X-ray crystallographic (Navia et al., 1989, Wlodawer et al., 1989) and biochemical analysis (Meek et al., 1989). A four-stranded antiparallel ß-sheet generated by interdigitating N-and C-termini of the monomers dominates the dimer interface. This ß-sheet is partially stabilized by intersubunit backbone H-bonds of alternate amino acids from each of the four strands.

Keywords

Human Immunodeficiency Virus Aspartyl Protease Human Immunodeficiency Virus Protease Alternate Amino Acid Active Human Immunodeficiency Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Lilia M. Babé
    • 1
  • Charles S. Craik
    • 1
  1. 1.Department of Pharmaceutical ChemistryUniversity of California, San FranciscoSan FranciscoUSA

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