Improved Chromatographic Method for the Assay of Retroviral Proteases

  • Hitoshi Hori
  • Tamami Takahashi
  • Atsushi Kato
  • Susumu Ueda
  • Hitoshi Kakidani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)

Abstract

The retroviral protease is essential for the maturation of infectious virus, and is therefore an attractive target for the design of antiviral drugs. To facilitate the screening of inhibitors of retroviral proteases, an improved chromatographic assay for the protease activity was developed.

Keywords

Hydrolysis Sucrose HPLC EDTA Leukemia 

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References

  1. 1.
    Y. Yamasaki, T. Kitamura, S. Nakatani and Y. Kato, J.Chromatogr. 481: 391–396 (1989).PubMedCrossRefGoogle Scholar
  2. 2.
    Y. Kato, S. Nakatan, T. Kitamura, Y. Yamasaki and T. Hashimoto, J. Chromatogr. 502: 416–422 (1990).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hitoshi Hori
    • 1
  • Tamami Takahashi
    • 1
  • Atsushi Kato
    • 2
  • Susumu Ueda
    • 2
  • Hitoshi Kakidani
    • 1
  1. 1.Biotechnology Research LaboratoryTOSOH CorporationJapan
  2. 2.Nippon Institute for Biological ScienceTokyoJapan

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