Abstract
HIV-1 and HIV-2 proteinases (PR) process the gag and gag-pol precursor polyproteins to produce the mature structural and enzymatic proteins found in infectious virus particles. These aspartic proteinases, from HIV-1 in particular, have been studied intensely since their discovery because they are attractive targets for therapeutic intervention in the treatment of AIDS. Antibodies which specifically recognize these proteinases were critical reagents in many of the experiments investigating the function of these proteinases. Here we describe the characterization of polyclonal and monoclonal antibodies against HIV-1 and HIV-2 PR.
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© 1991 Plenum Press, New York
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Stoller, T.J., Lim, J.J., Woltizky, B.A., Graves, M.C. (1991). Monoclonal and Polyclonal Antibodies: Reagents for Studying HIV-1 Proteinase Variants. In: Dunn, B.M. (eds) Structure and Function of the Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 306. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6012-4_66
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DOI: https://doi.org/10.1007/978-1-4684-6012-4_66
Publisher Name: Springer, Boston, MA
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