Monoclonal and Polyclonal Antibodies: Reagents for Studying HIV-1 Proteinase Variants
HIV-1 and HIV-2 proteinases (PR) process the gag and gag-pol precursor polyproteins to produce the mature structural and enzymatic proteins found in infectious virus particles. These aspartic proteinases, from HIV-1 in particular, have been studied intensely since their discovery because they are attractive targets for therapeutic intervention in the treatment of AIDS. Antibodies which specifically recognize these proteinases were critical reagents in many of the experiments investigating the function of these proteinases. Here we describe the characterization of polyclonal and monoclonal antibodies against HIV-1 and HIV-2 PR.
KeywordsHuman Immunodeficiency Virus Type Aspartic Proteinase Caprylic Acid Human Immunodeficiency Virus Protease Infectious Virus Particle
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