Aspartic Protease Inhibitors from the Parasitic Nematode Ascaris

  • Mark R. Martzen
  • Brad A. McMullen
  • Kazuo Fujikawa
  • Robert J. Peanasky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)


Ascaris suum and Ascaris hominis are intestinal endoparasitic nematodes. They live in hostile proteolytic environments and infect pigs and humans, respectively. Over one-quarter of the world’s human population (Muller, 1979) and masses of pigs are infected by these parasites. The resulting medical, agricultural and economic effects are significant (Levine, 1980; Mahmoud, 1989).


Circular Dichroism Spectrum Aspartic Protease Cyanogen Bromide Ascaris Lumbricoides Cytochemical Staining 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Mark R. Martzen
    • 1
  • Brad A. McMullen
    • 2
  • Kazuo Fujikawa
    • 2
  • Robert J. Peanasky
    • 3
  1. 1.Department of Neurobiology and AnatomyUniversity of RochesterRochesterUSA
  2. 2.Department of BiochemistryUniversity of WashingtonSeattleUSA
  3. 3.Department of Biochemistry and Molecular BiologyUniversity of South Dakota School of MedicineVermillionUSA

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