Expression of the HIV Aspartic Protease Fused to a Bacterial Phenotypic Marker

  • Bruce D. Korant
  • Chris J. Rizzo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)


The retroviruses encode a processing protease which is essential for virus replication. The enzyme is an aspartic protease, and cleaves both the gag and gag-pol gene products to yield mature virus containing active reverse transcriptase. In the absence of active protease only non-infectious viral particles are produced, so the enzyme has become an important target for drug designers, with the aim of benefiting people infected with the human immunodeficiency viruses, HIV-1 and HIV-2, and related retroviruses, which are agents of other serious diseases in man and domestic animals.


Aspartic Protease Periplasmic Space Active Reverse Transcriptase Total Cell Protein Viral Protease 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Bruce D. Korant
    • 1
  • Chris J. Rizzo
    • 1
  1. 1.Central Research & Development DepartmentDu Pont Experimental Station, E328WilmingtonUSA

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