X-Ray Structural Studies of Mammalian Aspartic Proteinases

  • J. B. Cooper
  • M. P. Newman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)


Pepsins are the major digestive enzymes of the alimentary canal and operate optimally at the low pH of the stomach. Pepsin A (EC., the major component of gastric juice in pigs, is produced by the mucosal cells of the fundus region of the stomach as an inactive precursor, pepsinogen. On secretion into the acidic lumen of the stomach, cleavage of the propart peptide occurs yielding active pepsin as a single chain molecule.


Mutant Enzyme Aspartic Proteinase Translation Function Rotation Function Active Site Cleft 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • J. B. Cooper
    • 1
  • M. P. Newman
    • 1
  1. 1.Laboratory of Molecular Biology and ICRF Unit of Structural Molecular Biology, Department of CrystallographyBirkbeck CollegeLondonUK

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