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X-Ray Structural Studies of Mammalian Aspartic Proteinases

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Book cover Structure and Function of the Aspartic Proteinases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 306))

Abstract

Pepsins are the major digestive enzymes of the alimentary canal and operate optimally at the low pH of the stomach. Pepsin A (EC.3.4.23.1), the major component of gastric juice in pigs, is produced by the mucosal cells of the fundus region of the stomach as an inactive precursor, pepsinogen. On secretion into the acidic lumen of the stomach, cleavage of the propart peptide occurs yielding active pepsin as a single chain molecule.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Biology and ICRF Unit of Structural Molecular Biology, Department of Crystallography, Birkbeck College, Malet Street, London, WC1E 7HX, UK

    J. B. Cooper & M. P. Newman

Authors
  1. J. B. Cooper
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  2. M. P. Newman
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Editor information

Editors and Affiliations

  1. University of Florida-College of Medicine, Gainesville, Florida, USA

    Ben M. Dunn

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© 1991 Plenum Press, New York

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Cooper, J.B., Newman, M.P. (1991). X-Ray Structural Studies of Mammalian Aspartic Proteinases. In: Dunn, B.M. (eds) Structure and Function of the Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 306. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6012-4_5

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  • DOI: https://doi.org/10.1007/978-1-4684-6012-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6014-8

  • Online ISBN: 978-1-4684-6012-4

  • eBook Packages: Springer Book Archive

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