Human Stomach Cathepsin E Action on Human Immunoglobulins
Human stomach mucosa contains four immunologically distinct aspartic proteinases-pepsin A, gastricsin or pepsin C (in the form of zymogens), cathepsin D and cathepsin E. Enzymatic properties, primary structure, cellular origin, activation mechanism and physiological role of pepsin, gastricsin and cathepsin D are well characterized. Much less information is available about cathepsin E although the enzyme has drawn much attention in recent years.
KeywordsAspartic Proteinase Human Immunoglobulin Peptide Hydrolysis Lymphoid Associate Tissue Amino Acid Preference
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- 3.T. E. Michaelsen, B. Fangione and E. C. Franklin, J.I mmunol. 119: 558–563 (1977).Google Scholar
- 6.B. M. Dunn, B. Parten, M. Jimenez, C. E. Rolph, M. J. Valler and J. Kay, in: “Aspartic Proteinases and their Inhibitors,” V. Kostka, ed., 221–243, W. de Gruyeter, Berlin (1985).Google Scholar
- 11.P. K. Ivanov, M. M. Chernaya, A. E. Gustchina, I. V. Pechik, S. V. Nikonov and N. I. Tarasova, Biochim. Biophys. Acta (in press) (1990).Google Scholar