Candida Albicans Acid Proteinase: Characterization and Role in Candidiasis
Candida albicans and related species are medically important yeast-like dimorphic fungi that are responsible, in part, for the rising incidence of serious, life-threatening opportunistic infections seen in immunocompromised and debilitated patients. In addition to minor localized infections of cutaneous, oropharyngeal and vaginal epithelium, Candida spp. produce transient or persistent fungemia that leads to systemic infections of virtually any organ (esp. liver, kidney and lung). Hematologic malignancy and transplant patients with prolonged neutropenia and antibiotic resistant fevers are particularly at risk. C. albicans and C. tropicalis are medically the most important, although other species do cause disease, but less frequently.
KeywordsCandida Albicans Candida Species None None Candida Infection Aspartic Proteinase
Unable to display preview. Download preview PDF.
- 16.R. Ruchel, K. Uhlemann and B. Boning. Secretion of acid proteinases by different species of the genus Candida, Zbl. Bakt. Hyg. I Abt. Orig. A 255: 537–548 (1983).Google Scholar
- 17.F.C. Odds, “Candida and Candidosis”, 2nd ed. W.B. Saunders, Publ., Philadelphia, PA. (1988).Google Scholar
- 21.T. L. Ray and C. D. Payne, Cytoplasmic Synthesis and Trans-Cell Wall Secretion of Acid Proteinase, a Virulence Factor, in Selected Switch Phenotypes of Candida albicans, Clin. Res. 38: 678A (1990).Google Scholar
- 22.R. Ruchel, On the role of proteinases from Candida albicans in the pathogenesis of acronecrosis, Zbl. Bakt. Hyg., I Abt. Orig. A 255: 524–536 (1983).Google Scholar
- 25.T. L. Ray and C. D. Payne, Detection of Candida acid proteinase (CAP) antibodies in systemic candidiasis by enzyme immunoassay, Clin. Res. 35: 711A (1987).Google Scholar
- 33.H. Kaminishi, Y. Hagihara, S. Hayashi and T. Cho, Isolation and characteristics of collagenolytic enzyme produced by Candida albicans. Infect. Immun. 53: 312–316 (1986).Google Scholar
- 37.R. Ruchel, On the renin-like activity of Candida proteinases and activation of blood coagulation in vitro, Zbl. Bakt. Hyg. I Abt. Orig. A 255: 368–379 (1983).Google Scholar
- 38.B. Slutsky, J. Boffo, and D. R. Soll, High frequency “switching” of colony morphology in Candida albicans, Science 230: 666–669 (1985).Google Scholar
- 41.T. L. Ray, C. D. Payne and D. R. Soll, Variable expression of Candida acid proteinase by “switch-phenotypes” of individual Candida albicans strains, Clin. Res. 36: 687A (1988).Google Scholar
- 42.T. L. Ray and C. D. Payne, Candida albicans acid proteinase: a role in virulence, in: “Microbial Determinants of Virulence and Host Response,” E. M. Ayoub, G. H. Cassell, W. C. Branche, Jr., and T. J. Henry, eds., Am Soc Microbiol, Washington, D.C. (1990).Google Scholar
- 43.T. L. Ray, C. D. Payne, B. J. Morrow and D. R. Soll, Switch phenotypes of Candida albicans strain WO-1 express diferent systemic and cutaneous virulence in murine models, Clin. Res. 37: 764A (1989).Google Scholar