Inhibitor Binding Induces Structural Changes in Porcine Pepsin
Crystal structures of several fungal aspartic proteinases have been refined at high resolution: penicillopepsin1, Endothia parasitica pepsin2 and Rhizopus chinensis protease.3 The structure of a recombinant form of human renin has been solved4 at 2.5 Å and the refined structures of two other mammalian aspartic proteinases have been reported recently: chymosin at 2.3 Å resolution5, and the monoclinic form of porcine pepsin at 2.3 and 1.8 Å resolution6,7, as well as the original hexagonal crystal form8.
KeywordsAspartic Proteinase Iodine Atom Fungal Enzyme Monoclinic Form Human Renin
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