Structure-Function Database for Active Site Binding to the Aspartic Proteinases
Aspartic Proteinases are produced in the human body by a variety of cells. Some of these proteins, for example, pepsin, gastricsin and renin are secreted and exert their effects in the extracellular spaces. Cathepsin D and cathepsin E, on the other hand, are intracellular enzymes.
KeywordsChromogenic Substrate Aspartic Proteinase Parent Peptide Human Cathepsin Side Chain Interaction
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- Abad-Zapatero, C., Rydel, T. J., Neidhart, D. J., Luly, J. and Erickson, J. W., Inhibitor binding induces structural changes in porcine pepsin, in: “Structure and Function of the Aspartic Proteinases: Genetics, Structures and Mechanisms,” Ben M. Dunn, ed., Plenum Press, New York.Google Scholar