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Reduction of Non-Steroidal Anti-Inflammatory Drug Induced Gastric Damage in the Rat by Soluble Pepstatin Derivatives

  • C. J. Grinham
  • C. J. Campbell
  • C. E. Barker
  • A. Baxter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)

Abstract

Chronic peptic ulceration is believed to result from an imbalance between aggressive (acid, pepsin) and defensive (bicarbonate, mucus) factors. Acute gastric ulceration often arises as a complication of trauma or surgery. The drugs used to treat peptic ulcers either inhibit acid secretion (e.g. H2-antagonists) or stimulate gastric defences (e.g. prostaglandins, bismuth salts). Neither therapy is ideal because of side effects and problems with recurrence. As there is now mounting evidence that pepsin might be important in the pathophysiology of peptic ulcer disease it was deemed important to study the beneficial effects of pepsin inhibitors.

Keywords

Peptic Ulcer Disease Gastric Damage Erosion Index Pepsin Activity Inhibit Acid Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baxter, A., Campbell, C. J., Grinham, C. J., Keane, R. M., Lawton, B. C. & Pendlebury, J. E., 1990, Biochem. J., 267: 665–669.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • C. J. Grinham
    • 1
  • C. J. Campbell
    • 1
  • C. E. Barker
    • 1
  • A. Baxter
    • 1
  1. 1.Department of BiochemistryGlaxo Group Research LtdGreenfordUK

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