Reduction of Non-Steroidal Anti-Inflammatory Drug Induced Gastric Damage in the Rat by Soluble Pepstatin Derivatives
Chronic peptic ulceration is believed to result from an imbalance between aggressive (acid, pepsin) and defensive (bicarbonate, mucus) factors. Acute gastric ulceration often arises as a complication of trauma or surgery. The drugs used to treat peptic ulcers either inhibit acid secretion (e.g. H2-antagonists) or stimulate gastric defences (e.g. prostaglandins, bismuth salts). Neither therapy is ideal because of side effects and problems with recurrence. As there is now mounting evidence that pepsin might be important in the pathophysiology of peptic ulcer disease it was deemed important to study the beneficial effects of pepsin inhibitors.
KeywordsPeptic Ulcer Disease Gastric Damage Erosion Index Pepsin Activity Inhibit Acid Secretion
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