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Consequences of Intramolecular Ionic Interactions for the Activation Rate of Human Pepsinogens A and C as Revealed by Molecular Modelling

  • Ruud A. Bank
  • Robert B. Russell
  • Gerard Pals
  • Michael N. G. James
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)

Abstract

The multigene family human pepsinogen A (PGA) consists of several isozymogens.1,2 DNA sequences for PGA-3, 4, and 5 have previously been reported.3 The substitutions between the various allozymogens (PGA residue numbering according to Evers et al.) are
  1. (1)

    PGA-3: Glu43, Val77,Gln207, Ala250, Leu338;

     
  2. (2)

    PGA-4: Glu43, Leu77,Lys207,Thr250,Val338 and

     
  3. (3)

    PGA-5: Lys43, Leu77, Gln207, Ala250, Leu338.

     

Keywords

Activation Rate Aspartic Proteinase Ionic Attraction Activation Segment Favorable Electrostatic Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ruud A. Bank
    • 1
    • 2
  • Robert B. Russell
    • 2
  • Gerard Pals
    • 1
  • Michael N. G. James
    • 2
  1. 1.Institute of Human GeneticsFree UniversityAmsterdamThe Netherlands
  2. 2.Medical Research Council of Canada, Group in Protein Structure and Function, Department of BiochemistryUniversity of AlbertaEdmontonCanada

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