Consequences of Intramolecular Ionic Interactions for the Activation Rate of Human Pepsinogens A and C as Revealed by Molecular Modelling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 306)
The multigene family human pepsinogen A (PGA) consists of several isozymogens.1,2 DNA sequences for PGA-3, 4, and 5 have previously been reported.3 The substitutions between the various allozymogens (PGA residue numbering according to Evers et al.) are
PGA-3: Glu43, Val77,Gln207, Ala250, Leu338;
PGA-4: Glu43, Leu77,Lys207,Thr250,Val338 and
PGA-5: Lys43, Leu77, Gln207, Ala250, Leu338.
KeywordsActivation Rate Aspartic Proteinase Ionic Attraction Activation Segment Favorable Electrostatic Interaction
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Press, New York 1991