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GRO: A Novel Chemotactic Cytokine

  • Ruth Sager
  • Stephen Haskill
  • Anthony Anisowicz
  • Douglas Trask
  • Marilyn C. Pike
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)

Abstract

Cytokines are small secreted regulatory peptides that act primarily in a paracrine fashion to provide a signalling system between different cell types. Although cytokine functions were initially associated with myeloid and lymphocytic responses to infection, current studies are demonstrating regulatory functions in growth and differentiation as well. Our studies with the GRO gene represent one of the first to describe a novel cytokine expressed by fibroblasts and epithelial cells as well as cells of the immune system, with regulatory functions both in growth and in the inflammatory response (1, 2, 3).

Keywords

Bladder Carcinoma Cell Line Infer Amino Acid Sequence Cytokine Function Lymphocytic Response Interferon Gene Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ruth Sager
    • 1
  • Stephen Haskill
    • 2
  • Anthony Anisowicz
    • 1
  • Douglas Trask
    • 1
  • Marilyn C. Pike
    • 3
  1. 1.Division of Cancer GeneticsDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of Obstetrics & Gynecology, Microbiology & Immunology Lineberger Cancer Research CenterUniversity of North Carolina at Chapel HillChapel HillUSA
  3. 3.Arthritis UnitMassachusetts General HospitalBostonUSA

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