GRO: A Novel Chemotactic Cytokine
Cytokines are small secreted regulatory peptides that act primarily in a paracrine fashion to provide a signalling system between different cell types. Although cytokine functions were initially associated with myeloid and lymphocytic responses to infection, current studies are demonstrating regulatory functions in growth and differentiation as well. Our studies with the GRO gene represent one of the first to describe a novel cytokine expressed by fibroblasts and epithelial cells as well as cells of the immune system, with regulatory functions both in growth and in the inflammatory response (1, 2, 3).
KeywordsBladder Carcinoma Cell Line Infer Amino Acid Sequence Cytokine Function Lymphocytic Response Interferon Gene Regulation
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