Induction and Regulation of Interleukin-8 Gene Expression

  • Robert M. Strieter
  • Theodore Standiford
  • Stephen W. Chensue
  • Keita Kasahara
  • Steven L. Kunkel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)


A variety of disease states are characterized by a significant infiltrate of polymorphonuclear leukocytes. These acute disorders can range from immune complex-mediated inflammation, such as glomerulonephritis and rheumatoid arthritis, to more enigmatic diseases (e.g. adult respiratory distress syndrome and psoriasis). An interesting aspect of many acute inflammatory reactions is the infiltrate that occurs during the initial reaction is nearly a pure population of neutrophils. If the inflammatory reaction persists, the histological picture evolves into a heterogeneous population of immune cells. Therefore, the recruitment of cells from the vascular compartment to the inflammatory lesion is a dynamic process and changes as the immune response evolves. This characteristic of an inflammatory lesion is a good example of the host’s ability to synthesize specific agents, which can elicit specific white blood cells, at specific time intervals of an inflammatory response.


Alveolar Macrophage Idiopathic Pulmonary Fibrosis Adult Respiratory Distress Syndrome Chemotactic Factor Chemotactic Cytokine 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Robert M. Strieter
    • 1
    • 2
  • Theodore Standiford
    • 1
    • 2
  • Stephen W. Chensue
    • 1
  • Keita Kasahara
    • 1
  • Steven L. Kunkel
    • 1
  1. 1.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Internal Medicine Division of Critical Care MedicineUniversity of Michigan Medical SchoolAnn ArborUSA

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