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NAP-1/IL-8 in Rheumatoid Arthritis

  • Ivan J. D. Lindley
  • Miroslav Ceska
  • Peter Peichl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)

Abstract

Neutrophil activating peptide 1, or interleukin-8 (NAP-1, IL-8), was isolated almost simultaneously by several groups as a neutrophil chemotactic or activating peptide from supernatants of endotoxin stimulated monocytes (1–5). The major form with 72 amino acids, and an approximate molecular weight of 8.4 kD, has since been shown to have activities on a variety of different cell types. It is chemotactic for neutrophils (PMN) and lymphocytes both in vitro and in vivo (6,2,4,7), and has been shown to stimulate PMN in vitro to degranulate and to exhibit respiratory burst (8,9), and thus has the basic attributes of an inflammatory mediator. Further actions which could be of great importance in inflammatory processes are chemotactic attraction of basophils, the triggering of IL-3 primed basophils to release leukotrienes and histamine (10), spasmogenic activity on airway smooth muscle (11), and effects on PMN adherence to endothelial cells (12).

Keywords

Synovial Fluid Airway Smooth Muscle Arthritic Joint Synovial Fluid Sample Arthritic Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ivan J. D. Lindley
    • 1
  • Miroslav Ceska
    • 1
  • Peter Peichl
    • 1
  1. 1.Sandoz ForschungsinstitutViennaAustria

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