Human Mesangial Cell-Derived Interleukin 8 and Interleukin 6: Modulation by an Interleukin 1 Receptor Antagonist

  • Zarin Brown
  • Lynette Fairbanks
  • Robert M. Strieter
  • Guy H. Neild
  • Steven L. Kunkel
  • John Westwick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)


The position and properties of the mesangial cell confer a major role for these cells in the regulation of renal function (1,2). Mesangial cells reside in the intercapillary space of the glomerulus and are embedded in an extracellular matrix. The interstitial region is unique in that entry of substances from the capillary lumen to the intercapillary space occurs without crossing a capillary basement membrane, the area is therefore well suited for a sieving function.


Mesangial Cell Human Mesangial Cell Mesangial Cell Proliferation Capillary Basement Membrane Mesangial Proliferative Glomerulonephritis 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Zarin Brown
    • 1
    • 2
  • Lynette Fairbanks
    • 1
    • 2
  • Robert M. Strieter
    • 3
  • Guy H. Neild
    • 2
  • Steven L. Kunkel
    • 3
  • John Westwick
    • 1
  1. 1.Department of Pharmacology, Hunterian InstituteRoyal College of SurgeonsLondonUK
  2. 2.Department of Renal Medicine, Institute of UrologyUniversity College and Middlesex School of MedicineLondonUK
  3. 3.Department of PathologyUniversity of MichiganAnn ArborUSA

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