Some Aspects of NAP-1 Pathophysiology: Lung Damage Caused by a Blood-Borne Cytokine
The neutrophil attracting/activating peptide (NAP-1), also called IL-8, was discovered as a result of its chemotactic activity for human neutrophils in vitro (1,2,3). In addition, NAP-1, similarly to other known chemotaxins, has potent neutrophil secretory activity in vitro (1,2,3). NAP-1 is the first described cytokine which attracts neutrophils and the first known chemoattractant acting on neutrophils, but not monocytes. Therefore, on the basis of its behaviour in vitro, one can suggest that NAP-1 and also the recently discovered NAP-2 (4) and NAP-3 (5) (all three belong to the C-X-C cytokine family, exhibit considerable structural homology and have analogous activities in vitro) could be responsible for the induction of the inflammatory cellular infiltrates dominated by neutrophils.
KeywordsAdult Respiratory Distress Syndrome Alveolar Septum Postcapillary Venule Chemotactic Cytokine Lung Damage
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