Interleukin-8 —A Mediator of Inflammatory Lung Disease?

  • Diana Smith
  • Lisa Burrows
  • John Westwick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)


Chronic inflammation is a feature of the airways of patients exhibiting lung diseases such as asthma, sarcoidosis and bronchitis. This has been recognised from autopsy studies of asthmatic airways (1) and has also been shown to be evident in the airways of asthmatics who have mild asthma (2) or are asymptomatic (3). Bronchial airway hyperreactivity (BHR) to a wide range of pharmacological and physical agents is one of the most characteristic features of asthmatic airways. It is known that intensification of BHR follows antigen challenge in atopic asthmatics (4) and it has been widely presumed that inflammatory events during late-onset reactions may determine the changes in airway reactivity (5).


Eosinophil Infiltration Atopic Asthmatic Airway Eosinophil Asthmatic Airway Major Basic Protein 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Diana Smith
    • 1
  • Lisa Burrows
    • 1
  • John Westwick
    • 1
  1. 1.Department of Pharmacology, Hunterian InstituteRoyal College of SurgeonsLondonUK

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