Chemotactic Cytokines in Inflammatory Skin Disease

  • Richard Camp
  • Kevin Bacon
  • Nicholas Fincham
  • Kay Mistry
  • Janet Ross
  • Frances Lawlor
  • Daniel Quinn
  • Andrew Gearing
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)


The production of cytokines in human skin in vivo has been investigated and found to be more selective than studies in vitro have suggested. Thus, stratum corneum samples from the skin lesions of psoriasis contain interleukin 8 (IL-8)-like material, but assay for a range of other compounds suggested that no other defined, biologically active cytokine was present in increased levels when compared with those in control heel stratum corneum samples. Selective cytokine release was also found on analysis of chamber fluid samples from the skin lesions of the cutaneous T-cell lymphoma, mycosis fungoides. Assay of normal epidermal samples has shown the presence of biologically active amounts of IL-1 like material, chromatographic purification and the use of neutralizing antibodies indicating the presence of IL-1α but negligible IL-1β activity in normal heel stratum corneum extracts. No other biologically active cytokine has been detected in normal skin. The IL-1α-like material recoverable from normal human epidermis possesses potent inflammatory properties when injected intradermally, but appears not to be biologically available under normal in vivo conditions, possibly through intracellular retention in keratinocytes, membrane association or control by an inhibitor. The release of preformed IL-1 following membrane perturbation or other events may constitute a primary mechanism for the induction of inflammation in human skin. For reasons to be outlined below, IL-1 may be less important in the maintenance of chronic inflammatory changes, at least in psoriasis, IL-8 possibly playing a more significant role.


High Performance Liquid Chromatography Stratum Corneum Normal Skin Mycosis Fungoides Intradermal Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Richard Camp
    • 1
  • Kevin Bacon
    • 1
  • Nicholas Fincham
    • 1
  • Kay Mistry
    • 1
  • Janet Ross
    • 1
  • Frances Lawlor
    • 1
  • Daniel Quinn
    • 1
  • Andrew Gearing
    • 1
    • 2
  1. 1.Institute of DermatologySt. Thomas’s HospitalLondonUK
  2. 2.British BiotechnologyOxfordUK

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