PDGF and the Small Inducible Gene (SIG) Family: Roles in the Inflammatory Response

  • Rodney S. Kawahara
  • Zheng-Wen Deng
  • Thomas F. Deuel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)


Inflammation and tissue repair involve a series of highly regulated and coordinated reactions that are beginning to be recognized and understood. Molecules ordinarily within intracellular compartments such as the platelet α-granule are released and appear to interact with target cells to initiate cell migration and division (1). The release of these factors and their interaction with cells stimulates a second wave of events through the transcriptional activation of genes which encode proteins with additional signalling roles (2,3). Inflammatory cells have been identified in close proximity to platelets in models of inflammation and immune complex disease and in lesions of atherosclerosis (4–8). These findings suggest close interactions and exchange of signals between platelets and inflammatory cells that mutually stimulate the release of these signalling molecules and initiate subsequent transcriptional events for the synthesis of additional mediators of inflammation and wound repair. Platelets may therefore play a central role in inflammation and tissue repair.


Glucocorticoid Receptor Platelet Factor Macrophage Inflammatory Protein Glucocorticoid Response Element Platelet Protein 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Rodney S. Kawahara
    • 1
  • Zheng-Wen Deng
    • 1
  • Thomas F. Deuel
    • 1
    • 2
  1. 1.Department of MedicineJewish Hospital at Washington University Medical CenterLouisUSA
  2. 2.Department of Biochemistry/Molecular BiophysicsJewish Hospital at Washington University Medical CenterLouisUSA

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