Mechanics of the Crossbridge Interaction in Living and Chemically Skinned Smooth Muscle
Force development in muscle is thought to result from cyclic attachment and detachment of crossbridges extending from “thick” myosin-containing filaments to binding sites on “thin” actin-containing filaments. According to the crossbridge model formulated by Huxley (1957) and extended by Huxley and Simmons (1971), the rate constants for attachment and detachment are functions of the position of the crossbridge relative to the binding site on the actin filament, which also determines the force by the elastic extension of the crossbridge. Particularly, “negative” strain on the crossbridge, giving rise to a force tending to oppose shortening of the muscle, is associated with a high rate constant for crossbridge detachment.
KeywordsLength Step Force Response Phasic Contraction Tonic Contraction Taenia Coli
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