In Vitro Evidence for Smooth Muscle Crossbridge Mechanical Interactions
Force production and shortening in smooth muscle result from the cyclic interaction between myosin crossbridges and actin filaments. Although the crossbridge mechanism in smooth muscle is qualitatively similar to that in skeletal muscle, smooth muscle has the unique ability of sustaining prolonged contractions with very little energy expenditure (Butler and Siegman, 1983). This economy of energy consumption may reflect a modulation of crossbridge cycling rate within the time course of a contraction. Investigators have postulated that this modulation is related to the regulatory processes that govern the crossbridge’s interaction with actin.
KeywordsActin Filament Myosin Light Chain Motility Assay Myosin Filament Smooth Muscle Myosin
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