Platelet Activating Factor Causes Relaxation of Isolated Pulmonary Artery and Aorta
Platelet activating factor (PAF) is a lipid chemical mediator produced by a variety of activated cells, including basophils, eosinophils, platelets, monocytes, endothelial cells, macrophages, and neutrophils (Tamura, 1987; Vercellotti, 1988). A number of pathophysiological responses, such as inflammatory and allergic reactions, bronchoconstriction, platelet aggregation, pulmonary hypertension, anaphylactic shock, endotoxic shock, and systemic hypotension are mediated by PAF (Benveniste and Vargaftig, 1983; Heffner, 1983a; 1983b; Terashita, 1985; 1987; Hanahan, 1986; Barnes, 1988). These pathological conditions are linked to changes in smooth muscle tone. For example, bronchoconstriction is due to the increase in tone of airway smooth muscle and hypotension is due to the decrease in tone of vascular smooth muscle.
KeywordsPulmonary Hypertension Platelet Activate Factor Airway Smooth Muscle Aortic Ring Anaphylactic Shock
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