In Vitro Synaptic Transmission in Sympathetic Neuron-Vascular Smooth Muscle Co-Cultures
It is well established that nerves can have a direct and dramatic influence over the phenotypic expression and behavior of target tissues. This has been most thoroughly documented in the skeletal muscles, where denervation results in a reduction of resting membrane potential, appearance of tetrodotoxin-insensitive Na+ channels, and development of supersensitivity associated with the spread of acetylcholine (ACh) -receptors to extrajunctional membranes (Patrick et al., 1978; Fambrough, 1979). Furthermore, the type of innervation and pattern of stimulation on the skeletal muscle fibers can change the phenotype of the muscle, i.e. from a fast to slow type (Eisenberg et al., 1984).
KeywordsVascular Smooth Muscle Cell Sympathetic Neuron Horse Radish Peroxidase Repetitive Stimulation Cerebral Arteriole
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