In Vitro Synaptic Transmission in Sympathetic Neuron-Vascular Smooth Muscle Co-Cultures

  • Donald G. Ferguson
  • Stephanie A. Lewis
  • Raymund Y. K. Pun
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 304)


It is well established that nerves can have a direct and dramatic influence over the phenotypic expression and behavior of target tissues. This has been most thoroughly documented in the skeletal muscles, where denervation results in a reduction of resting membrane potential, appearance of tetrodotoxin-insensitive Na+ channels, and development of supersensitivity associated with the spread of acetylcholine (ACh) -receptors to extrajunctional membranes (Patrick et al., 1978; Fambrough, 1979). Furthermore, the type of innervation and pattern of stimulation on the skeletal muscle fibers can change the phenotype of the muscle, i.e. from a fast to slow type (Eisenberg et al., 1984).


Vascular Smooth Muscle Cell Sympathetic Neuron Horse Radish Peroxidase Repetitive Stimulation Cerebral Arteriole 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Donald G. Ferguson
    • 1
  • Stephanie A. Lewis
    • 1
  • Raymund Y. K. Pun
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Cincinnati College of MedicineCincinnatiUSA

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