Isotonic Shortening Parameters but not Isometric Force Development are Altered in Ragweed Pollen Sensitized Canine Bronchial Smooth Muscle
Studies on airway smooth muscle can serve two major purposes. First, the elucidation of basic mechanisms and properties of smooth muscle contraction and its regulation can be obtained. The trachealis, for example, provides a plentiful source of relatively pure smooth muscle tissue for studies at biochemical and molecular levels. In addition, both tracheal and bronchial smooth muscles furnish us with an optimal preparation for studying mechanical properties because their respective muscle fibers are oriented in a parallel fashion. The second purpose in studying airway smooth muscle is in characterizing the pathophysiology of asthma with hopes of advancing disease management. On this tack, we have a canine model of the disease (Kepron et al., 1977), in which dogs are immunized from birth with ragweed pollen. These animals demonstrate a generalized sensitization of their smooth muscles to the pollen antigen (Antonissen et al., 1979; Antonissen et al., 1980; Kong and Stephens, 1983; Wang et al., 1990). Concomitantly, they produce high IgE anti-ragweed antibody titers and show marked increases in airflow resistance upon aerosolized, specific antigen bronchoprovocation (Becker et al., 1989).
KeywordsSmooth Muscle Airway Smooth Muscle Smooth Muscle Contraction Muscle Strip Bronchial Smooth Muscle
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