Increased ATPase Activity and Myosin Light Chain Kinase (MLCK) Content in Airway Smooth Muscle from Sensitized Dogs
The bronchial hyperreactivity associated with acute asthma appears to be a manifestation of alterations in the regulatory pathways governing airway smooth muscle function (Stephens et al., 1988; Jiang et al., 1990; Kong et al., 1990). We have developed a canine model of asthma (Kepron et al., 1977), in which newborn dogs are sensitized to ragweed pollen using an intraperitoneal immunization regime.
KeywordsATPase Activity Airway Smooth Muscle Myosin Light Chain Kinase Bronchial Smooth Muscle Tracheal Smooth Muscle
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- Aksoy, M. O., Mras, S., Kamm, K. E., and Murphy, R. A., 1983, Ca2+, cAMP, and changes in myosin phosphorylation during contraction of smooth muscle, Am. J. Physiol., 245: C255.Google Scholar
- Bendall, J. R., 1964, The myofibrillar ATPase activity of various animals in relation to ionic strength and temperature, in: “Biochemistry of Muscle Contraction”, J. Gergely, ed., Little Brown, Boston, p. 448.Google Scholar
- Jiang, H., Rao, K., Halayko, A. J., Kepron, W., and Stephens, N. L., 1990, Mechanical alterations in sensitized (S) canine bronchial smooth muscle (BSM), FASEB J., 4: A444.Google Scholar
- Stephens, N. L., Kong, S. K., and Seow, C. Y., 1988, Mechanisms of increased shortening of sensitized airway smooth muscle, in: “Mechanisms of Asthma: Pharmacology, Physiology, and Management”, C. L. Armour, J. L. Black, eds., Alan R. Liss, New York, p. 231.Google Scholar