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Increased ATPase Activity and Myosin Light Chain Kinase (MLCK) Content in Airway Smooth Muscle from Sensitized Dogs

  • Kang Rao
  • He Jiang
  • Andrew J. Halayko
  • Nan Pan
  • Wayne Kepron
  • Newman L. Stephens
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 304)

Abstract

The bronchial hyperreactivity associated with acute asthma appears to be a manifestation of alterations in the regulatory pathways governing airway smooth muscle function (Stephens et al., 1988; Jiang et al., 1990; Kong et al., 1990). We have developed a canine model of asthma (Kepron et al., 1977), in which newborn dogs are sensitized to ragweed pollen using an intraperitoneal immunization regime.

Keywords

ATPase Activity Airway Smooth Muscle Myosin Light Chain Kinase Bronchial Smooth Muscle Tracheal Smooth Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kang Rao
    • 1
  • He Jiang
    • 1
  • Andrew J. Halayko
    • 1
  • Nan Pan
    • 1
  • Wayne Kepron
    • 1
  • Newman L. Stephens
    • 1
  1. 1.Department of Physiology Faculty of MedicineUniversity of ManitobaWinnipegCanada

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