Advertisement

Altered Excitation-Contraction Coupling in Hypertension: Role of Plasma Membrane Phospholipids and Ion Channels

  • Robert H. Cox
  • Thomas N. Tulenko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 304)

Abstract

Established hypertension is characterized by an elevation of peripheral resistance (Frohlich, 1973). A variety of in vivo studies in human as well as animal models of hypertension have demonstrated augmented responsiveness of arterial smooth muscle to contractile agents (Triggle, 1989). However, identification of the cellular mechanisms responsible for this increased responsiveness has proven elusive. Most older in vitro studies of maximum contractile responses as well as of the sensitivity of isolated vascular smooth muscle to agonists failed to reveal augmented responses in hypertensive arteries (Cox, 1989; Mulvany, 1989; Triggle, 1989). Folkow proposed the hypothesis that increased arterial wall thickness which impinged on the lumen was responsible for an increased geometric component of peripheral resistance as well as the augmented in vivo smooth muscle responsiveness to agonists in hypertension (Folkow, 1973). The latter was thought to be the result of an amplifying effect of the increased wall thickness being translated into augmented resistance responses to smooth muscle activation (Folkow, 1973). This hypothesis was generally accepted as a reconciliation of the results reported up to the mid 1970s.

Keywords

Arterial Smooth Muscle Cell Uterine Smooth Muscle Small Mesenteric Artery Small Resistance Artery Smooth Muscle Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bárány M, 1967, ATPase activity of myosin correlated with speed of muscle shortening, J. Gen. Physiol, 50: 197.PubMedCrossRefGoogle Scholar
  2. Benga, G. and Holmes, R. P., 1984, Interactions between components in biological membranes and their implications for membrane function, Prog. Biophys. Mol. Biol, 43: 195.PubMedCrossRefGoogle Scholar
  3. Bialecki R. and Tulenko T. N., 1989, Excess membrane cholesterol alters calcium channel activity in smooth muscle of rabbit carotid artery, Am. J. Physiol., 257:C306.Google Scholar
  4. Bing, R. F., Heagerty, P. M., Thurston, H., and Swales, J. D., 1986, Ion transport in hypertension: Are changes in the cell membrane responsible?, Clin. Sci., 71: 225.PubMedGoogle Scholar
  5. Borochov, H., Zahler, P., Wilbrandt, W., and Shinitzky, M., 1977, Effect of phosphatidylcholine to sphingomyelin mole ratio on the dynamic properties of sheep erythrocytes membrane, Biochim. Biophys. Acta, 470: 382.CrossRefGoogle Scholar
  6. Broderick, R., Bialecki, R., and Tulenko, T. N., 1989, Cholesterol-induced changes in arterial sensitivity to adrenergic stimulation, Am. J. Physiol, 257: H170.Google Scholar
  7. Carey, R. A., Bove, A. A., Coulson, R. L., and Spann, J. F., 1979, Correlation between cardiac muscle myosin ATPase activity and velocity of shortening, Biochem. Med., 21: 235.PubMedCrossRefGoogle Scholar
  8. Chacko, S. and Cox, R. H., 1981, Contractile protein content of arteries from normotensive (WKY) and spontaneously hypertensive rats (SHR), Fed. Proc, 40: 575.Google Scholar
  9. Cohen, M. L. and Berkowitz, B. A., 1976, Vascular contraction: Effect of age and extracellular calcium, Blood Vessels, 13: 139.PubMedGoogle Scholar
  10. Cox, R. H., 1981, Basis for the altered arterial wall mechanics in the spontaneously hypertensive rat, Hypertension, 3: 485.PubMedGoogle Scholar
  11. Cox, R. H., 1982a, Time course of arterial wall changes with DOCA plus salt hypertension in the rat, Hypertension, 4: 27.PubMedGoogle Scholar
  12. Cox, R. H., 1982b, Changes in arterial wall properties during development and maintenance of renal hypertension, Am. J. Physiol., 242: H477.Google Scholar
  13. Cox, R. H., 1989, Mechanical properties of arteries in hypertension, in: “Blood Vessel Changes in Hypertension: Structure and Function Vol. 1”, R. M. K. W. Lee, ed., CRC Press, Boca Raton, p. 65.Google Scholar
  14. Cox, R. H., Katzka, D., and Morad, M., 1990, Characteristics of calcium current in single isolated rabbit portal vein myocytes, Biophys. J., 57: 526a.Google Scholar
  15. Cox, R. H., Katzka, D., and Morad, M., 1990, Characteristics of inactivation of calcium currents in freshly isolated rabbit portal vein myocytes, FASEB J., 4: A441.Google Scholar
  16. Cox, R. H. and Kikta, D. C., 1989, Comparison of norepinephrine (NE) activated 86Rb efflux in arteries from genetically obese Zucker rats, FASEB J., 3: A1009.Google Scholar
  17. Dukes, I. and Morad, M., 1990, Tedisamil inactivates transient outward K+ current in rat ventricular myocytes, Am. J. Physiol., 257: H1746.Google Scholar
  18. Erne, P. and Hermsmeyer, K., 1989, Intracellular vascular muscle Ca2+ modulation in genetic hypertension, Hypertension, 14: 145.PubMedGoogle Scholar
  19. Fleisch, J. H., 1980, Age-related changes in the sensitivity of blood vessels to drugs, Pharmacol. Ther., 8: 477.PubMedCrossRefGoogle Scholar
  20. Folkow, B., Hallback, M., Lundgren, Y., Sivertsson, R., and Weiss, L., 1973, Importance of adaptive changes in vascular design for establishment of primary hypertension, studied in man and in spontaneously hypertensive rats, Circ. Res., 32(Suppl I): 2.PubMedGoogle Scholar
  21. Frohlich, E. D., 1973, Clinical significance of hemodynamic findings in hypertension, Chest, 64: 94.PubMedCrossRefGoogle Scholar
  22. Gleason, M. M. and Tulenko, T., 1989, Excess cholesterol alters calcium fluxes and membrane fluidity in cultured arterial smooth muscle cells, Circulation, 80: 11–63.Google Scholar
  23. Graham, R. M., Pettinger, W. A., Sagalowsky, A., Brabson, J., and Gandler, T., 1982, Renal alpha-adrenergic receptor abnormality in the spontaneously hypertensive rat, Hypertension, 4: 881.PubMedGoogle Scholar
  24. Hauser, H. and Phillips, M. C., 1979, Interactions of the polar head groups of phospholipid bilayer membranes, in: “Progress in Surface Membrane Science”, D. A. Cadenheaad and J. F. Danielli, eds., Academic Press, New York, p. 297.Google Scholar
  25. Henry, P. D., 1984, Hyperlipidemic arterial dysfunction, Circulation, 81: 697.CrossRefGoogle Scholar
  26. Hermsmeyer, K., 1984, Altered arterial muscle ion transport mechanism in the spontaneously hypertensive rat, J. Cardiovasc. Pharmacol., 6: S10.PubMedCrossRefGoogle Scholar
  27. Hruza, Z. and Zweifach, B. W., 1967, Effect of age on vascular reactivity to catecholamines in rats, J. Gerontology, 22: 469.Google Scholar
  28. Ives, H. E., 1989, Ion transport defects in hypertension. Where is the link?, Hypertension, 14: 590.PubMedGoogle Scholar
  29. Johansson, B., 1984, Different types of smooth muscle hypertrophy, Hypertension, 6(Suppl III): 11–64.Google Scholar
  30. Jones, A. W., 1973, Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats. Influences of aldosterone, norepinephrine and angiotensin, Circ. Res., 33: 563.PubMedGoogle Scholar
  31. Jones, A. W., 1980, Content and fluxes of electrolytes, in: “The Handbook of Physiology; The Cardiovascular System: Vascular Smooth Muscle”, D. F. Bohr, A. P. Somlyo, and H. V. Sparks Jr., eds., American Physiological Society, Bethesda, p. 253.Google Scholar
  32. Jones, A. W. and Smith, J. M., 1986, Altered Ca-dependent fluxes of 42K in rat aorta during aldosterone-salt hypertension, in: “Recent Advances in Arterial Disease: Atherosclerosis, Hypertension and Vasospasm”, T. N. Tulenko and R. H. Cox, eds., Alan R. Liss, New York, p. 265.Google Scholar
  33. Kass, R. S. and Krafte, D. S., 1987, Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines, J. Gen. Physiol, 89: 629.PubMedCrossRefGoogle Scholar
  34. Kim, Y. S., Samuel, M., Levin, R. M., and Chacko, S., 1990, Characteristics of the contractile and cytoskeletal proteins of the hypertrophied urinary bladder smooth muscle, J. Urology, 143: 35A.Google Scholar
  35. Locher, O. H., Neyes, L., Stimple, M., Kuffer, B., and Vetter, W., 1984, The cholesterol content of the human erythrocyte influences calcium influx through the channel, Biochem. Biophys. Res. Comm., 124: 822.PubMedCrossRefGoogle Scholar
  36. Madden, T. D., King, M. D., and Quinn, P. J., 1981, The modulation of Ca++-ATPase activity of sarcoplasmic reticulum by membrane cholesterol — the effect of enzyme coupling, Biochim. Biophys. Acta, 641: 265.PubMedCrossRefGoogle Scholar
  37. Matlib, M. A., Schwartz, A., and Yamori, Y., 1985, A Na+-Ca2+ exchange process in isolated sarcolemmal membranes of mesenteric arteries of WKY and SHR, Am. J. Physiol., 249: C166.PubMedGoogle Scholar
  38. McMahon, E. G. and Paul, R. J., 1985, Calcium sensitivity of isometric force in intact and chemically skinned aortas during the development of aldosterone-salt hypertension in the rat, Circ. Res., 56: 427.PubMedGoogle Scholar
  39. Medow, M. S. and Segal, S., 1987, Age-related changes in fluidity of rat renal brush border membrane vesicles, Biochem. Biophys. Res. Comm., 142: 849.PubMedCrossRefGoogle Scholar
  40. Mulvany, M. J. and Nyborg, N., 1980, An increased calcium sensitivity of mesenteric resistance vessels in young and adult spontaneously hypertensive rats, Br. J. Pharmacol., 71: 585.PubMedGoogle Scholar
  41. Mulvany, M. J., 1989, Contractile properties of resistance vessels related to cellular function, in: “Blood Vessel Changes in Hypertension: Structure and Function, Vol. 1”, R. M. K. W. Lee, ed., CRC Press, Boca Raton, p. 1.Google Scholar
  42. Mulvany, M. J. and Halpern, W., 1977, Contractile properties of small resistance vessels in spontaneously hypertensive and normotensive rats, Circ. Res., 41: 19.PubMedGoogle Scholar
  43. Nishizuka, Y., 1984, Turnover of inositol phospholipids and signal transduction, Science, 225: 1365.PubMedCrossRefGoogle Scholar
  44. Owens, G. K., 1991, Role of contractile agonists in growth regulation of vascular smooth muscle cells, in: “Cellular and Molecular Mechanisms in Hypertension”, R. H. Cox, ed., Plenum Press, New York, in press.Google Scholar
  45. Packer, C. S. and Stephens, N. L., 1985, Force-velocity relationships in hypertensive arterial smooth muscle, Can. J. Physiol. Pharmacol., 63: 669.PubMedCrossRefGoogle Scholar
  46. Pagani, E. D. and Julian, F. J., 1984, Rabbit papillary muscle myosin isoenzymes and the velocity of muscle shortening, Circ. Res., 54: 586.PubMedGoogle Scholar
  47. Quinn, P. J., 1980, The fluidity of cell membranes and its regulation, Prog. Biophys. Mol Biol., 38: 1.CrossRefGoogle Scholar
  48. Rock, D. E. and Tulenko, T. N., 1991, Excess membrane cholesterol and atherosclerosis impair ATP-dependent K+ channel activation in arterial smooth muscle cells, FASEB J., 5: A532.Google Scholar
  49. Rusch, N. J. and Hermsmeyer, K., 1988, Calcium currents are altered in the vascular muscle cell membrane of spontaneous hypertensive rats, Circ. Res., 63: 997.PubMedGoogle Scholar
  50. Schnitzky, M. and Barenholz, Y., 1978, Fluidity parameters of lipid regions determined by fluorescence polarization, Biochim. Biophys. Acta., 515: 367.Google Scholar
  51. Somlyo, A. P., 1985, Excitation-contraction coupling and the ultrastructure of smooth muscle, Circ. Res., 57: 497.PubMedGoogle Scholar
  52. Stekiel, W. J., Contney, S. J., and Lombard, J. H., 1986, Small vessel membrane potential, sympathetic input, and electrogenic pump rate in SHR, Am. J. Physiol, 250:C547.PubMedGoogle Scholar
  53. Sugiyama, T., Yoshizumi, M., Takaku, F., and Yazaki, Y., 1990, Abnormal calcium handling in vascular smooth muscle cells of spontaneously hypertensive rats, J. Hypertension, 8: 369.CrossRefGoogle Scholar
  54. Triggle, C. R., 1989, Reactivity and sensitivity changes of blood vessels in hypertension, in: “Blood Vessel Changes in Hypertension: Structure and Function, Vol. 1”, R. M. K. W. Lee, ed., CRC Press, Boca Raton, p. 25.Google Scholar
  55. Tulenko, T. N., Bialecki, R., Gleason, M., and D’Angelo, G., 1990, Ion channels, membrane lipids and cholesterol: A role for membrane lipid domains in arterial function, in: “Potassium Channels: Basic Function and Therapeutic Aspects”, T. Colatsky, ed., Alan R. Liss, New York, p. 187.Google Scholar
  56. Tulenko, T. N., Rabinowitz, J. L., Cox, R. H., and Santamore, W. P., 1988, Altered Na+/K+-ATPase, cell Na+ and lipid profiles in canine arterial wall with chronic cigarette smoking, Eur. J. Biochem., 20: 285.Google Scholar
  57. Tulenko, T. N., Lapatofsky, D., and Cox, R. H., 1988, Alterations in membrane phospholipid bilayer composition with age in the Fisher 344 rat, Physiologist, 31: A138.Google Scholar
  58. Upadhya, A., Fariel, M. R., Bagshaw, R. J., Cox, R. H., and Chacko, S., 1986, Alteration of the contractile proteins of the arterial muscle in hypertension, Fed. Proc, 45: 1074.Google Scholar
  59. van Blitterswijk, W. B., van der Meer, B., and Hilkmann, H., 1987, Quantitative contributions of cholesterol and the individual classes of phospholipids and their degree of fatty acyl (un)saturation to membrane fluidity measured by fluorescence polarization, Biochemistry, 26: 1746.PubMedCrossRefGoogle Scholar
  60. Webb, R. C. and Bohr, D. F., 1978, Mechanism of membrane stabilization by calcium in vascular smooth muscle, Am. J. Physiol, 235: C227.PubMedGoogle Scholar
  61. Whall Jr., C. W., Myers, M. M., and Halpern, W., 1980, Norepinephrine sensitivity, tension development and neuronal uptake in resistance arteries from spontaneously hypertensive and normotensive rats, Blood Vessels, 17: 1.PubMedGoogle Scholar
  62. White, R. E. and Carrier, G. O., 1988, Enhanced alpha-adrenergic neuroeffector system in diabetes: importance of calcium, Am. J. Physiol., 255: H1036.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Robert H. Cox
    • 1
  • Thomas N. Tulenko
    • 2
  1. 1.Bockus Research InstituteThe Graduate HospitalPhiladelphiaUSA
  2. 2.Department of PhysiologyMedical College of PennsylvaniaPhiladelphiaUSA

Personalised recommendations