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Structure-Function Analysis of the HIV Glycoprotein

  • John W. Dubay
  • Hae-ja Shin
  • Jian-yun Dong
  • Susan Roberts
  • Eric Hunter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 303)

Abstract

The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion. Both polypeptides are encoded in the env gene of the virus and are synthesized in the form of a polyprotein precursor that is proteolytically cleaved during its transport to the surface of the cell. While these proteins are not required for the assembly of enveloped virus particles, they do play a critical role in the virus replication cycle by recognizing and binding to specific receptors, via the SU domain, and by mediating the fusion of viral and cell membranes, via the TM domain: virus particles lacking envelope glycoproteins are thus non-infectious.

Keywords

Rous Sarcoma Virus Glycoprotein Precursor Potential Cleavage Site Precursor Cleavage Dibasic Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • John W. Dubay
    • 1
  • Hae-ja Shin
    • 1
  • Jian-yun Dong
    • 1
  • Susan Roberts
    • 1
  • Eric Hunter
    • 1
  1. 1.Department of MicrobiologyUniversity of Alabama at BirminghamBirminghamUSA

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