Autoimmune Recognition Profile of the Alpha Chain of Human Acetylcholine Receptor in Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disease with skeletal muscle weakness and easy fatigability due to autoantibodies directed against acetylcholine receptor (AChR) molecules at the motor endplates. The AChR consists of 2 alpha (α) subunits and one each of beta, gamma and delta subunit in a circular arrangement. Studies have shown that major populations of the autoantibodies are directed against extracellular domains of the α subunit which bears binding sites for the ligands and α-toxin (reviewed in Ashizawa and Appel, 1985; Atassi et al, 1987).
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