Modified-Live Infectious Bovine Rhinotracheitis Virus (IBRV) Vaccine Expressing Foot-and-Mouth Disease Virus (FMDV) Capsid Protein Epitopes on Surface of Hybrid Virus Particles
Foot-and-Mouth Disease (FMD) is a highly contagious disease of cattle and other cloven hoofed animals caused by a Picornavirus. It is enzootic in most South American countries, where hundreds of outbreaks are recorded each year, and endemic in many Asian, Middle East, African and European countries. The disease can spread rapidly due to its short incubation period and contagious nature and has a dramatic impact on livestock production and trade. In countries where FMD is endemic, binary ethylenimine-inactivated vaccines have been widely used to control disease. Annual production of FMD vaccine worldwide is probably between 700 and 800 million doses. Nearly 500 million doses are applied to cattle annually (Bahnemann, 1990). Yet, despite intensive vaccination programs, outbreaks of FMD occurred in 22 countries in the last quarter of 1989 (Foreign Animal Disease Report of USDA-APHIS,No. 18-2. Summer 1990).
KeywordsElectron Dense Core Cloven Hoofed Animal Synthetic Peptide Vaccine Infectious Bovine Rhinotracheitis Virus Infectious FMDV
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