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Protection against Streptococcal Pharyngeal Colonization with Vaccines Composed of M Protein Conserved Regions

  • V. A. Fischetti
  • D. E. Bessen
  • O. Schneewind
  • D. E. Hruby
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 303)

Abstract

Group A streptococci are widespread human pathogens which are responsible for nasopharyngeal infections and impetigo. There are over 25 million cases of group A streptococcal infections each year in the United States alone, at a cost of over $1 billion to the public. Despite the fact that streptococcal infection can be successfully treated with antibiotics, in the interim it often causes significant discomfort and loss in productivity. Furthermore, about 3% of infected individuals afflicted with streptococcal infection develop a more serious illness such as rheumatic fever and rheumatic heart disease. Because rheumatic heart disease occurs in as many as 1% of school-age children in developing countries (Agarwal, 1981; Dodu and Bothig, 1989), there is a strong impetus to develop a safe and effective vaccine against group A streptococcal pharyngitis.

Keywords

Vaccinia Virus Rheumatic Fever Rabies Virus Rheumatic Heart Disease Streptococcal Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • V. A. Fischetti
    • 1
  • D. E. Bessen
    • 1
  • O. Schneewind
    • 1
  • D. E. Hruby
    • 2
  1. 1.The Rockefeller UniversityNew YorkUSA
  2. 2.Center for Gene Research and Biotechnology, Department of MicrobiologyOregon State UniversityCorvallisUSA

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