Protection against Streptococcal Pharyngeal Colonization with Vaccines Composed of M Protein Conserved Regions
Group A streptococci are widespread human pathogens which are responsible for nasopharyngeal infections and impetigo. There are over 25 million cases of group A streptococcal infections each year in the United States alone, at a cost of over $1 billion to the public. Despite the fact that streptococcal infection can be successfully treated with antibiotics, in the interim it often causes significant discomfort and loss in productivity. Furthermore, about 3% of infected individuals afflicted with streptococcal infection develop a more serious illness such as rheumatic fever and rheumatic heart disease. Because rheumatic heart disease occurs in as many as 1% of school-age children in developing countries (Agarwal, 1981; Dodu and Bothig, 1989), there is a strong impetus to develop a safe and effective vaccine against group A streptococcal pharyngitis.
KeywordsVaccinia Virus Rheumatic Fever Rabies Virus Rheumatic Heart Disease Streptococcal Infection
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- Bessen, D. & Fischetti, V.A. 1988b, Vaccination againstinfection, in: New Generation Vaccines,Levine, M.M. & Wood, G., Eds., Marcel Dekker,Inc, New York, p 599.Google Scholar
- Bessen, D. & Fischetti, V.A. 1988d, Role of nonopsonic antibody in protection against group A streptococcal infection, in: Technological Advances in Vaccine Development, Lasky, L., Ed., Alan R. Liss Inc., New York, p 493.Google Scholar
- Bessen, D. and Fischetti, V.A, 1990, Differentiation between two biologically distinct classes of group A streptococci by limited substitutions of amino acids within the shared region of M protein-like molecules, J. Exp. Med. In pressGoogle Scholar
- Bisno, A.L. 1980, The concept of rheumatogenic and nonrheumatogenic group A streptococci, in: Streptococcal diseases and the immune response, Read, S.E. & Zabriskie, J.B., Eds., Academic Press, New York. p 789.Google Scholar
- Breese, B.B. & Hall, C.B. (1978), Beta hemolytic streptococcal diseases. Houghton MifflinGoogle Scholar
- Boston, Cohen, C. and Parry, D.A.D., 1986, Alpha-helical coiled coils-a widespread motif in proteins, T. I. B. s 11:245.Google Scholar
- Hruby, D.E., Schneewind, O., Wilson, E.M. and Fischetti, V.A, 1990, Assembly and analysis of a functional vaccinia virus amplicon containing the C-repeat region from the M protein of Streptococcus pyogenes. Submitte.Google Scholar
- Signas, G, Raucci, G., Jonsson, K., Lindgren, P., Anantharamaiah, G.M., Hook, M. and Lindberg, M., 1989, Nucleotide sequence of the gene for fibronectin-binding protein from Staphylococcus aureus: Use of this peptide sequence in the synthesis of biologically active peptides, Proc. Natl. Acad. Sci. USA 86:699.PubMedCrossRefGoogle Scholar