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Critical Events in Skin Tumor Promotion and Progression

  • Thomas J. Slaga
Part of the Basic Life Sciences book series (BLSC, volume 57)

Abstract

Carcinogenesis in skin as well as other target tissues in a number of species has been shown to be a multistage process which can be divided into at least three major stages, initiation, promotion and progression. An important aspect of the multistage skin carcinogenesis is that it has suggested that both genetic and epigenetic mechanisms are important. Altered growth control and differentiation leading to a more embryonic phenotype appear to be critical consequences of the genetic and epigenetic changes.

Keywords

Benzoyl Peroxide Mouse Skin Skin Tumor Dark Cell Mouse Epidermis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Thomas J. Slaga
    • 1
  1. 1.M. D. Anderson Cancer Center, Science Park-Research Division, Department of CarcinogenesisThe University of TexasSmithvilleUSA

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