Critical Events in Skin Tumor Promotion and Progression
Carcinogenesis in skin as well as other target tissues in a number of species has been shown to be a multistage process which can be divided into at least three major stages, initiation, promotion and progression. An important aspect of the multistage skin carcinogenesis is that it has suggested that both genetic and epigenetic mechanisms are important. Altered growth control and differentiation leading to a more embryonic phenotype appear to be critical consequences of the genetic and epigenetic changes.
KeywordsBenzoyl Peroxide Mouse Skin Skin Tumor Dark Cell Mouse Epidermis
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