Early and Late Events in the Development of Human Breast Cancer
There is a large body of literature using various model systems to address early events in neoplastic transformation. These studies (which encompass various suggested etiologic agents such as viruses, carcinogens, hormones and growth factors, oncogenes, radiation, etc.) all focus on the target cell itself. However, carcinomas arise in organized tissues where there is a close association with mesenchymal cells and their secreted products. Hence, it is reasonable to consider the possibility that abnormal stromal tissue may actively participate in some events of the malignant process. A number of recent studies suggest that this view may be particularly relevant for the induction of breast cancer. These studies provide evidence at the cellular and biochemical level that the fibroblasts obtained from breast cancer patients differ from those of normal women.
KeywordsBreast Cancer Hyaluronic Acid Human Breast Cancer Skin Fibroblast Allelic Loss
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