Characterization of the Stage of Progression in Hepatocarcinogenesis in the Rat

  • Henry C. Pitot
Part of the Basic Life Sciences book series (BLSC, volume 57)


The concept of neoplastic progression as a stage in the natural history of neoplastic development was first enunciated by Foulds1. He distinguished the stage of initiation as that which established “a persistent region of incipient neoplasia whence tumors of varied kinds emerge at a later time”2. All of the remainder of neoplastic development he termed progression. In a sense, such a concept was quite analogous to that proposed earlier by several authors as the stages of initiation and promotion3. Interestingly, the basis for the development of these two concepts of multistage carcinogenesis were, respectively, experimental mammary adenocarcinoma and epidermal carcinoma in mice. In retrospect, more emphasis was placed on the development of malignant lesions in the concept of progression, whereas early benign and preneoplastic lesions were emphasized as characteristic of the stage of promotion during multistage epidermal carcinogenesis. It is only during the last decade that these two general concepts have been reconciled on the basis of an increased understanding and characterization of the early stages of development, initiation and promotion, with the relegation of the term progression to the final stage of neoplastic development, in which the malignant characteristics and genetic heterogeneity of neoplasms appear4.


Karyotypic Change Multistage Carcinogenesis Neoplastic Development Canine Transmissible Veneral Tumor Intermediate Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Henry C. Pitot
    • 1
  1. 1.McArdle Laboratory for Cancer Research, Departments of Oncology and Pathology, The Medical SchoolUniversity of Wisconsin-MadisonMadisonUSA

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