Cancer Genes by Non-Homologous Recombination

  • Peter H. Duesberg
  • David Goodrich
  • Ren-Ping Zhou
Part of the Basic Life Sciences book series (BLSC, volume 57)


The only proven cancer genes to date are the onc genes of directly transforming retroviruses1–4. These are autonomous transforming genes because they transform diploid cells in culture with single hit kinetics, and because all susceptible cells become transformed as soon as they are infected. Accordingly, tumors induced by such viruses in animals are all polyclonal. Such viruses have never been found in healthy animals, a statement that cannot be made for retroviruses without onc genes or DNA tumor viruses, which are commonly found in animals outside the laboratory and only transform cells indirectly and inefficiently5–7.


Long Terminal Repeat Cancer Gene Diploid Cell Rous Sarcoma Virus Cellular Oncogene 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Peter H. Duesberg
    • 1
  • David Goodrich
    • 1
  • Ren-Ping Zhou
    • 1
  1. 1.Department of Molecular BiologyUniversity of CaliforniaBerkeleyUSA

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