Tumor Progression in Transgenic Mice Containing the Bovine Papillomavirus Genome
Transgenic mice are an interesting system to study a variety of biological phenomena. It has been a particularly interesting way of studying oncogenesis. It has provided a tractable system to study and to dissect the multiple steps involved in carcinogenesis, essentially by fixing one of these steps1. In transgenic mice, DNA is introduced into the germ line and that gene is stably inherited to the offspring of the mice. Transgenic mice have been developed using a 1.69 tandemly reiterated copy of the bovine papillomavirus type 1 (BPV-1) genome2. BPV-1 encodes two different viral oncogenes, and in the transgenic line of mice that has been developed, these two viral oncogenes are under the control of the transcriptional regulatory sequences of the virus to ensure proper tissue specific expression of the viral oncogenes.
KeywordsTransgenic Mouse Human Papilloma Virus Dermal Fibroblast Viral Oncogene Viral Gene Expression
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