KCl Cotransport in HbAA and HbSS Red Cells: Activation by Intracellular Acidity and Disappearance During Maturation

  • J. Clive Ellory
  • Andrew C. Hall
  • Susan A. Ody
  • Carlos E. Poli de Figueiredos
  • Susan Chalder
  • John Stuart
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 307)


Low intracellular pH was shown to be a potent activator of the KCl cotransport system in HbSS red cells, and in reticulocyte-rich fractions of HbAA red cells. Rheological experiments indicated that cell dehydration via the KCl cotransporter in response to low pH decreased the filterability of HbSS red cells. In vitro maturation experiments showed that the KCl cotransport system was rendered cryptic rapidly, in contrast to choline transport, and serine transport via system ASC, which disappeared much more slowly.


High Hydrostatic Pressure Mean Cell Volume Choline Transport Mean Cell Haemoglobin Concentration Amino Acid Transport Activity 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • J. Clive Ellory
    • 1
  • Andrew C. Hall
    • 1
  • Susan A. Ody
    • 1
  • Carlos E. Poli de Figueiredos
    • 1
  • Susan Chalder
    • 2
  • John Stuart
    • 2
  1. 1.Department of PhysiologyUniversity of OxfordOxfordUSA
  2. 2.Department of HaematologyUniversity of Birmingham, Medical SchoolBirminghamUSA

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