Opsonic Potential of C3b-Anti-Band 3 Complexes when Generated on Senescent and Oxidatively Stressed Red Cells or in Fluid Phase
Covalently linked complexes of complement component C3b and IgG (C3b-IgG complexes) were found predominantly on senescent rather than young red cells (1,2). They contained anti-band 3 as verified after cleavage of the hydroxylamine sensitive bond between C3b and IgG by studying the specificity of the liberated and purified IgG molecules (3,4). Two aspects of these C3b-IgG complexes are striking: a) their apparently exclusive formation with anti-band 3 and b) their presumptive opsonic potency as judged from comparison with artificially made C3b-IgG complexes (5–7).
KeywordsFluid Phase Swiss Federal Institute Thioester Bond Oligomerized Band Erythrocyte Membrane Glycoprotein
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