Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging
Human red blood cells (RBC) as well as the erythrocytes of many mammals are removed from circulation at the end of their life by an impressively efficient biological mechanism that is not fully understood. It is commonly accepted that senescent erythrocytes are selectively recognized and removed from the circulation by spleen and liver macrophages (1), however, various mechanisms have been proposed to account for this selectivity (for a review see Blood Cells vol. 14, 1988). Among these, the immunologic mechanism of cellular removal is widely accepted although the precise identity of the senescent cell antigen(s) remains to be established and primary mechanism of red blood cell aging leading to immunoglobins and complement binding have yet to be elucidated.
KeywordsProteolytic System Hexokinase Activity Glycolytic Rate Surface Immunoglobulin Senescent Erythrocyte
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